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His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy. [ 10 ] Wilder's colleague, paediatrician Mynie Gustav Peterman , later formulated the classic diet, with a ratio of one gram of protein per kilogram of body weight in children, 10–15 g of carbohydrate per day, and the remainder of ...
Once diagnosed, a medically supervised ketogenic diet is usually recommended as it can help to control seizures. [21] The ketogentic diet is the current standard of care treatment, with 80% of patients having >90% seizure reduction [ 13 ] and improving some movement disorders in approximately two thirds of GLUT1 deficiency patients. [ 18 ]
In extreme cases the resulting acetone can be detected in the patient's breath as a faint, sweet odor. There are some health benefits to ketone bodies and ketogenesis as well. It has been suggested that a low-carb, high fat ketogenic diet can be used to help treat epilepsy in children. [6] Additionally, ketone bodies can be anti-inflammatory. [19]
The ketogenic diet, characterized by low carbohydrates and high fat consumption, has become increasingly popular over the last decade or so. As a result, ketone drinks or supplements have boomed.
Alanine is a direct precursor in gluconeogenesis and can be used for treatment of ketotic hypoglycemia. If an episode begins, affected children should be given fluids and carbohydrate-rich foods immediately, if swallowing is not compromised. [2] A carbohydrate gel can be applied to the inside of the mouth in children who are unable to swallow.
The most detailed study to date conducted in aging male mice reveals some of the mechanisms through which a ketogenic diet may help protect the aging brain. How keto diets may help boost memory ...