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In situ follicular lymphoma is an accumulation of monoclonal B cells (i.e. cells descendent from a single ancestral cell) in the germinal centers of lymphoid tissue. These cells commonly bear a pathological genomic abnormality, i.e. a translocation between position 32 on the long (i.e. "q") arm of chromosome 14 and position 21 on chromosome 18's q arm.
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Primary cutaneous follicle center lymphoma is a type of lymphoma. [1] It was recognized as a distinct disease entity in the 2008 WHO classification. [ 2 ] : 218 PCFCL had been previously conceived as a variant of follicular lymphoma (FL).
When used to uniquely identify a type of lymphoma, they are usually categorized as follicular or diffuse . The "small cleaved cells" are usually centrocytes that express B-cell markers such as CD20. The disease is strongly correlated with the genetic translocation t(14;18), which results in juxtaposition of the bcl-2 proto-oncogene with the ...
English: Histology of cell types in a germinal center: A centrocyte, a centroblast and a follicular dendritic cell, seen in a follicular lymphoma, H&E stain. - Centrocytes are small to medium size with angulated, elongated, cleaved, or twisted nuclei.
Duodenal-type follicular lymphoma (DFL) is a form of lymphoma in which certain lymphocyte types, the B-cell-derived centrocytes and centroblasts, form lymph node follicle-like structures principally in the duodenum and other parts of the small intestine.
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