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One phase II trial evaluated faricimab's efficacy and safety in comparison to ranibizumab and showed clinically meaningful and statistically significant improvements in visual acuity. [ 12 ] [ 20 ] Two phase III multi-center randomized studies were completed on 1,891 diabetic participants with diabetic macular edema (DME).
An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. [1] [2] α-Synuclein is a protein which is thought to be involved in the development and progression of α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.
145 309.21 g·mol −1: Rinucumab (REGN2176) is a monoclonal antibody designed for the treatment of neovascular age-related macular degeneration. [1] [2]
145 639.02 g·mol −1 Emicizumab , sold under the brand name Hemlibra , is a humanized bispecific monoclonal antibody for the treatment of haemophilia A , developed by Genentech and Chugai (both organizations are subsidiaries of Hoffmann-La Roche ). [ 4 ]
The approval was based on the results of the RAISE trial, a phase III study, which compared ramucirumab plus irinotecan, folinic acid, and 5-fluorouracil to FOLFIRI alone. [ 13 ] In May 2019, ramucirumab was approved by FDA as a single agent treatment for hepatocellular carcinoma (HCC) in patients who have an alpha fetoprotein (AFP) of > 400 ng ...
[1] [4] [2] It is a tissue factor pathway inhibitor (TFPI) antagonist. [4] It was developed by Pfizer. [ 5 ] Marstacimab is a new type of medication that, rather than replacing a clotting factor, works by reducing the amount, and therefore, the activity of, the naturally occurring anticoagulation protein called tissue factor pathway inhibitor ...
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The Phase 2 dose of Demcizumab was 3.5 mg/kg every two weeks for 70 days. [4] [5] [6] In April 2017, OncoMed announced that the trial had failed to meet its primary endpoint and demcizumab had no significant effect on survival. [7] The other phase 2 trial is the Denali trial for non-small cell lung cancer.