Ad
related to: is cortisol gene transcript positive meaning pdf
Search results
Results From The WOW.Com Content Network
Because the receptor gene is expressed in several forms, it has many different (pleiotropic) effects in different parts of the body. When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. [5] [6] The unbound receptor resides in the cytosol of the cell. After the receptor is bound to ...
The goal is to normalize the production of 21-hydroxylase, the enzyme encoded by CYP21A2. Providing a working copy of this gene may improve adrenal hormone synthesis and subsequently normalize cortisol and aldosterone production. [253] Currently, gene replacement therapy for CAH is still at an early stage of research and development.
Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.When used as medication, it is known as hydrocortisone.. It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in an adrenal gland. [1]
In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Cortisol, a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it also binds the mineralcorticoid receptor at higher concentrations. Both aldosterone and cortisol have a similar affinity for the mineralocorticoid receptor; however, there is vastly more cortisol in circulation than ...
Late onset congenital adrenal hyperplasia (LOCAH), also known as nonclassic congenital adrenal hyperplasia (NCCAH or NCAH), is a milder form of congenital adrenal hyperplasia (CAH), [1] a group of autosomal recessive disorders characterized by impaired cortisol synthesis that leads to variable degrees of postnatal androgen excess.
In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. This protective mechanism is necessary because cortisol circulates at 100- to 1000-fold higher concentrations than aldosterone, and binds with equal affinity to the ...
26423 Ensembl ENSG00000136931 ENSMUSG00000026751 UniProt Q13285 P33242 RefSeq (mRNA) NM_004959 NM_139051 NM_001316687 RefSeq (protein) NP_004950 NP_004950.2 NP_001303616 NP_620639 Location (UCSC) Chr 9: 124.48 – 124.51 Mb Chr 2: 38.58 – 38.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex ...