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All clinical experience with NCT to date is with boron-10; hence this method is known as boron neutron capture therapy (BNCT). [1] Use of another non-radioactive isotope, such as gadolinium, has been limited to experimental animal studies and has not been done clinically.
Boron neutron capture therapeutics are pharmaceuticals used to deliver boron-10 to cancerous cells as part of boron neutron capture therapy (BNCT). Boron-10 atoms strongly absorb neutrons to form a metastable state of boron-11, which undergoes α-decay. By accumulating boron-10 in cancerous cells and subjecting the tumor to neutron radiation ...
Each salient feature of the reactor was designed in relation to its use for therapy and diagnosis or in the advancement of basic medical science.” [3] One of the treatments pioneered at this reactor was boron neutron capture therapy, or BNCT. This promising treatment was developed for use against glioblastoma multiforme, an otherwise ...
The MURR contributes to research in boron neutron capture therapy, neutron scattering and neutron interferometry, neutron transmutation doping of semiconductor materials, use of radioisotopes for imaging and treatment of cancer, epidemiology, and archaeology, along with many others.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Boron_neutron_capture_therapy&oldid=1073675500"
Boron neutron capture therapy (BNCT) involves injecting a boron-10 tagged chemical that preferentially binds to tumor cells. Neutrons from a nuclear reactor are shaped by a neutron moderator to the neutron energy spectrum suitable for BNCT treatment. The tumor is selectively bombarded with these neutrons.
The role of the boron atom in neutron capture therapy for malignant brain tumors is to target tumor cells selectively. When a non-radioactive boron isotope ( 10 B ) is administered and accumulates in tumor cells, these cells can be selectively destroyed when irradiated with low-energy thermal neutrons.
There he was a Harvard-MIT Health Sciences and Technology Whitaker Fellow, where he helped research the application of boron-neutron capture therapy for malignant brain tumors. In 1979, Pettigrew received his M.D. from the Miller School of Medicine at the University of Miami in a then-novel program which only admitted students who already held ...