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Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, accounting for about 15% of all primary malignant brain tumors.
Surgery is the first stage of treatment of glioblastoma. An average GBM tumor contains 10 11 cells, which is on average reduced to 10 9 cells after surgery (a reduction of 99%). Benefits of surgery include resection for a pathological diagnosis, alleviation of symptoms related to mass effect, and potentially removing disease before secondary ...
Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components. [3] Primary gliosarcoma (PGS) is classified as a grade IV tumor and a subtype of glioblastoma multiforme in the 2007 World Health Organization classification system (GBM). [ 4 ]
Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for astrocytoma and as the first-line treatment for glioblastoma. [ 4 ] [ 6 ] [ 7 ] Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer . [ 8 ]
John McCain suffers from a highly malignant form of cancer that spreads quickly due to its association with a large network of blood vessels in the brain. What is glioblastoma? McCain’s brain ...
The treatment is highly effective for certain blood cancers, but scientists are still studying whether modified versions of CAR-T therapy can be used for solid tumors like glioblastoma. These ...
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