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Before June 2011, synthetic cannabinoids were relatively unknown in Australia. [101] However, compulsory employee drug tests at Western Australian mines found that 1 in 10 employees had consumed compounds found in synthetic cannabinoids. [102]
Because synthetic cannabinoid molecular structures differ from THC and other illegal cannabinoids, synthetic cannabinoids were not technically illegal. Since the discovery of the use of synthetic cannabinoids for recreational use in 2008, some synthetic cannabinoids have been made illegal , but new analogs are continually synthesized to avoid ...
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Botanix Pharmaceuticals is listed on the Australian Securities Exchange with the issue code BOT. The Company is headquartered in Perth, Western Australia and Philadelphia, USA. It is a clinical stage synthetic [1] cannabinoid [2] company, focusing on the compound Cannabidiol. [3]
5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in e-cigarette form as C-Liquid) [1] is an indazole-3-carboxamide based synthetic cannabinoid. [2] 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with the original patent claiming approximately 4x selectivity for CB 1, having an EC 50 of <0.1 nM for human CB 1 receptors and 0.37 nM for human CB 2 receptors. [3]
Compared with classical cannabinoids, synthetic cannabinoids differ structurally. Some common synthetic cannabinoids are available in the market such as JWH-018, which is the most well-known naphthoylindole and JWH-250, a phenylacetylindole. They are sold under the brand name ”Spice” as a recreational drug over the past decade.
JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman.It is a methylated analogue of JWH-018.It has a K i of 0.69 nM at CB 1 and 1.2 nM at CB 2. [2]In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, California, that was laced with JWH-122.
JWH-200 (WIN 55,225 [1]) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, K i at the CB 1 receptor is 42 nM, around the same as that of THC, [2] but its analgesic potency in vivo was higher than that of other analogues with stronger CB 1 binding affinity in vitro, [3] around 3 times that of THC but with less sedative ...