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Myoblasts (cells with a single nucleus, represented in violet) fusing together to form muscle fibers (multinucleated muscle cells) during myogenesis. Myogenesis is the formation of skeletal muscular tissue, particularly during embryonic development.
The rate of muscle formation from C2C12 cells can be controlled by the introduction of loss-of-functions genes vital for the fusion of myoblasts and myogenesis. [7] Under necrotic conditions, such as tumor necrosis factor alpha , direct protein loss, particularly myosin heavy chain protein, in C2C12 skeletal muscle cells has been shown. [8]
Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. [5] It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle.
Skeletal muscle cells form by fusion of myoblasts to produce multinucleated cells in a process known as myogenesis. [ 4 ] [ 5 ] Skeletal muscle cells and cardiac muscle cells both contain myofibrils and sarcomeres and form a striated muscle tissue .
Skeletal muscle (commonly referred to as muscle) is one of the three types of vertebrate muscle tissue, the others being cardiac muscle and smooth muscle. They are part of the voluntary muscular system [ 1 ] and typically are attached by tendons to bones of a skeleton .
Muscle is formed during embryonic development, in a process known as myogenesis. [2] Skeletal muscle tissue is striated consisting of elongated, multinucleate muscle cells called muscle fibers, and is responsible for movements of the body. Other tissues in skeletal muscle include tendons and perimysium. [3]
MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation.MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as myogenic regulatory factors (MRFs). [7]
Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4. In mice, myogenin is essential for the development of functional ...