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  2. Replicon (genetics) - Wikipedia

    en.wikipedia.org/wiki/Replicon_(genetics)

    According to the replicon model, two components control replication initiation: the replicator and the initiator. The replicator is the entire DNA sequence (including, but not limited to the origin of replication) required to direct the initiation of DNA replication.

  3. Origin of replication - Wikipedia

    en.wikipedia.org/wiki/Origin_of_replication

    More than five decades ago, Jacob, Brenner, and Cuzin proposed the replicon hypothesis to explain the regulation of chromosomal DNA synthesis in E. coli. [18] The model postulates that a diffusible, trans-acting factor, a so-called initiator, interacts with a cis-acting DNA element, the replicator, to promote replication onset at a nearby origin.

  4. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    Replication Factories Disentangle Sister Chromatids. The disentanglement is essential for distributing the chromatids into daughter cells after DNA replication. Because sister chromatids after DNA replication hold each other by Cohesin rings, there is the only chance for the disentanglement in DNA replication. Fixing of replication machineries ...

  5. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    Eukaryotic DNA replication is a conserved mechanism ... both the replicons merge to complete the process of replication. Meanwhile, the second replicon is moving in ...

  6. Replisome - Wikipedia

    en.wikipedia.org/wiki/Replisome

    The replication of bacteriophage T4 DNA upon infection of E. coli is a well-studied DNA replication system. During the period of exponential DNA increase at 37°C, the rate of elongation is 749 nucleotides per second. [11] The mutation rate during replication is 1.7 mutations per 10 8 base pairs. [12]

  7. DNA re-replication - Wikipedia

    en.wikipedia.org/wiki/DNA_re-replication

    The DNA re-replication response is different from the response taken when damage is due to oxygen radical generation. Damage from oxygen radical generations leads to a response from the Myc oncogene, which phosphorylates p53 and H2AX. [16] The ATM/ATR DNA damage network will also respond to cases where there is an overexpression of Cdt1.

  8. DnaA - Wikipedia

    en.wikipedia.org/wiki/DnaA

    DnaA is a protein that activates initiation of DNA replication in bacteria. [1] Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular chromosome called the replicator to start DNA replication. [2] It is a replication initiation factor which promotes the unwinding of DNA at oriC. [1]

  9. Licensing factor - Wikipedia

    en.wikipedia.org/wiki/Licensing_factor

    A licensing factor is a protein or complex of proteins that allows an origin of replication to begin DNA replication at that site. Licensing factors primarily occur in eukaryotic cells, since bacteria use simpler systems to initiate replication. However, many archaea use homologues of eukaryotic licensing factors to initiate replication. [1]