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Common, all ages, [8] typically children under 5 years [2] Adenovirus infection is a contagious viral disease , caused by adenoviruses , commonly resulting in a respiratory tract infection . [ 1 ] [ 9 ] Typical symptoms range from those of a common cold , such as nasal congestion , rhinitis , and cough , to difficulty breathing as in pneumonia ...
In an investigation of 5 children with an inflammation of the liver of unknown cause at Birmingham, Alabama in October 2021, all turned out to have human adenovirus 41. [6] In August 2022, 9 children in a U.S. case series of hepatitis of unknown cause [7] and 27 of 30 children in a U.K. case series with hepatitis of unknown cause who underwent ...
Although the basic chemical reaction is the same for both tyrosine and serine recombinases, there are some differences between them. [13] Tyrosine recombinases, such as Cre or FLP, cleave one DNA strand at a time at points that are staggered by 6–8bp, linking the 3' end of the strand to the hydroxyl group of the tyrosine nucleophile (Fig. 1 ...
The P1 gene product was named Cre (cyclization recombination) and the recombination site was named loxP (locus of crossing (x) over, P1). [5] The Cre protein was purified in 1983 and was found to be a 35,000 Da protein. [2] No high energy cofactors such as ATP or accessory proteins are required for the recombinase activity of the purified ...
A type of adenoviral keratoconjunctivitis in very young children can present with a high fever, sore throat, ear infection, vomiting and diarrhea. [ 3 ] It is commonly caused by types 8 and 37 adenoviruses , spread by contaminated eye examination instruments and eye solutions, touching eyes by infected people, from inadequately chlorinated ...
Prevention of adenovirus, as well as other respiratory illnesses, involves frequent hand washing for more than 20 seconds, avoiding touching the eyes, face, and nose with unwashed hands, and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus infection are additionally advised to cough or ...
In genetics, Flp-FRT recombination is a site-directed recombination technology, increasingly used to manipulate an organism's DNA under controlled conditions in vivo.It is analogous to Cre-lox recombination but involves the recombination of sequences between short flippase recognition target (FRT) sites by the recombinase flippase (Flp) derived from the 2 μ plasmid of baker's yeast ...
A diagram describing how Lox71 and Lox66 sites can be used to combine two plasmids into one contiguous plasmid. When cells that have loxP sites in their genome express Cre, a recombination event can occur between the loxP sites. Cre recombinase proteins bind to the first and last 13 bp regions of a lox site forming a dimer.