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Intellia Therapeutics, Inc. is an American clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies. The company's in vivo programs use intravenously administered CRISPR as the therapy, in which the company's proprietary delivery technology enables highly precise ...
Several CRISPR-Cas systems identified through the company's metagenomics-based protein discovery platform, including members of the Casφ and Cas14 families of CRISPR-associated enzymes, have demonstrated potential for therapeutic genome editing in in vivo settings. [2]
The company is headquartered in Cambridge, Massachusetts. In the development of therapies, the company relies on CRISPR and prime editing , whereby single nucleotides in a DNA sequence can be modified without cutting the DNA, theoretically reducing the likelihood of off-target effects compared to previous CRISPR-based methods [ vague ] .
The gene-editing therapy specialist is rising in prominence. For premium support please call: 800-290-4726 more ways to reach us
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland.It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases.
CRISPR-Cas9 genome editing techniques have many potential applications. The use of the CRISPR-Cas9-gRNA complex for genome editing [10] was the AAAS's choice for Breakthrough of the Year in 2015. [11] Many bioethical concerns have been raised about the prospect of using CRISPR for germline editing, especially in human embryos. [12]
Colossal's lab will pair CRISPR/Cas9 with other DNA-editing enzymes, such as integrases, recombinases, and deaminases, to splice woolly mammoth genes into the Asian elephant. [22] The company plans on sequencing both elephant and mammoth samples in order to identify key genes in both species to promote population diversification.
CRISPRpedia — a free textbook-style resource for learning about the biology, applications, and ethics of CRISPR and genome editing, with chapters edited by Doudna, Urnov, Ronald, and other IGI investigators. [68] [69] CRISPR Made Simple — an educational guide to CRISPR for younger students and teachers. [70]