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The potential efficacy of probiotics to treat AAD depends on the probiotic strains and dosage. [ 100 ] [ 101 ] One review recommended for children L. rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony-forming units/day, given the modest number needed to treat and the likelihood that adverse events are very rare. [ 94 ]
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It is uncommonly reported as a human pathogen and is widely used as a probiotic in Japan, Korea, and China. [1] C. butyricum is a soil inhabitant in various parts of the world, has been cultured from the stool of healthy children and adults, and is common in soured milk and cheeses. [ 2 ]
These are also called injectable formulations and are used with intravenous, subcutaneous, intramuscular, and intra-articular administration. The drug is stored in liquid or if unstable, lyophilized form. Many parenteral formulations are unstable at higher temperatures and require storage at refrigerated or sometimes frozen conditions.
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