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If cancer has spread beyond the uterus, radiation, chemotherapy, and hormonal therapy may be used. If detected in its early stages, survival rates for uterine sarcoma are 66% after 5 years. If cancer has spread beyond the uterus, the survival rate declines to approximately 13-34%. [1]
Symptoms: Endometrial cancer: vaginal bleeding, pelvic pain [1] Uterine sarcoma: vaginal bleeding, mass in the vagina [2] Types: Endometrial cancer, uterine sarcoma [3] Risk factors: Endometrial cancer: obesity, metabolic syndrome, type 2 diabetes, tamoxifen use, unopposed estrogens, late menopause, family history of the condition [1]
As with endometrial carcinomas, the prognosis is influenced by the grade and type of the adenocarcinoma, being poorest with serous differentiation. MMMTs are highly malignant; a stage I tumor has an expected five-year survival rate of 50%, while the overall five-year survival rate is less than 20%. [1] Staging of uterine MMMTs is as follows: [3]
It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy, prompted by post-menopausal bleeding. Unlike the more common low-grade endometrioid endometrial adenocarcinoma, uterine serous carcinoma does not develop from endometrial hyperplasia and is not hormone ...
C and D. Immunohistochemistry of p53 shows that high-grade serous carcinoma cells are diffusely positive for p53, a pattern consistent with a missense TP53 mutation while the adjacent epithelial cells from the background serous borderline tumor are only focally and weakly positive, a pattern consistent with a wild-type TP53 sequence.
Endometrial cancer is sometimes called "uterine cancer", although it is distinct from other forms of cancer of the uterus such as cervical cancer, uterine sarcoma, and trophoblastic disease. [9] The most frequent type of endometrial cancer is endometrioid carcinoma, which accounts for more than 80% of cases. [3]
In cancer types with high survival rates, incidence is usually higher in the developed world, where longevity is also greater. Cancers with lower survival rates are more common in developing countries. [6] The highest cancer survival rates are in countries such as South Korea, Japan, Israel, Australia, and the United States. [7]
Ovarian cancer incidence rates are low in East Asia [56] and highest in Europe, the United States, and Australia/New Zealand. [ 57 ] Since 1975, survival rates for ovarian cancer have steadily improved with a mean decrease of 51% by 2006 of risk of death from ovarian cancer for an advanced stage tumour. [ 58 ]