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Preclinical imaging is the visualization of living animals for research purposes, [1] such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes.
Endomicroscopy is a technique for obtaining histology-like images from inside the human body in real-time, [1] [2] [3] a process known as ‘optical biopsy’. [4] [5] It generally refers to fluorescence confocal microscopy, although multi-photon microscopy and optical coherence tomography have also been adapted for endoscopic use.
Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates.. It is enabled by techniques for hyperpolarization of carbon-13-containing molecules using dynamic nuclear polarization and rapid dissolution to create an injectable solution.
Imaging Core: The Advanced Imaging Core at MMRI was developed to facilitate the non-invasive analysis of preclinical models of disease. [3] Equipment includes: Perkin Elmer IVIS Spectrum – 2D and 3D optical imaging; Perkin Elmer Quantum GX microCT – x-ray computed tomography imaging; Visual Sonics Vevo 3100 Ultrasound – high frequency ...
Fluorescence imaging photographs fluorescent dyes and fluorescent proteins to mark molecular mechanisms and structures. It allows one to experimentally observe the dynamics of gene expression, protein expression, and molecular interactions in a living cell. [3] It essentially serves as a precise, quantitative tool regarding biochemical ...
High resolution 99m Tc-MDP mouse scan acquired with a stationary SPECT system: animated image of rotating maximum intensity projections.. Preclinical or small-animal Single Photon Emission Computed Tomography is a radionuclide based molecular imaging modality for small laboratory animals [1] (e.g. mice and rats).
The first intravascular in vivo use in a preclinical model was reported in 1994 [6] and first in human, clinical imaging in 2003. [7] The first OCT imaging catheter and system was commercialized by LightLab Imaging, Inc., a company based in Massachusetts formed following a technology transfer in 1997 from Fujimoto's lab (MIT). [8]
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.