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An axo-axonic synapse is a type of synapse, formed by one neuron projecting its axon terminals onto another neuron's axon. [ 1 ] Axo-axonic synapses have been found and described more recently than the other more familiar types of synapses, such as axo-dendritic synapses and axo-somatic synapses.
From your first comment, Debivort, you raise the issue of the synapse being connected to the soma, but this is not necessarily wrong, as presynaptic axons often synapse with postsynaptic neuron's body, creating an axosomatic synapse. Not all synapses are axodendritic synapses. See this image. There are some issues to clear up with the terms ...
This image is a derivative work of the following images: File:Synapse_Illustration2_tweaked.svg licensed with Cc-by-sa-3.0-migrated, GFDL 2008-05-06T07:26:21Z Delldot 862x555 (181497 Bytes) {{Information |Description=Synapse. Tweaked version of [[:Image:SynapseIllustration2.png]]: spelling corrections, increased text size, minor tweaks.
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In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm. [3] Synaptic vesicles are relatively simple because only a limited number of proteins fit into a sphere of 40 nm diameter.
In addition, the size of postsynaptic densities of axospinous and axosomatic synapses is sexually dimorphic, with males having larger density than females. Estrogen plays an important role in modulating the sexually dimorphic synaptic connectivity of VMN. Estradiol levels are high on proestrus rats and return to low levels on diestrus rats.
A neural connection is formed when an axosomatic synapse is created Adult expression. In a study done in rat spinal cords, increased netrin-1, UNC-5 homologue levels were observed compared to lower levels measured in the embryo. [10] From this study multiple mRNA transcripts were detected by northern blot analysis.
Axon terminals contain synaptic vesicles that store the neurotransmitter for release at the synapse. This makes multiple synaptic connections with other neurons possible. Sometimes the axon of a neuron may synapse onto dendrites of the same neuron, when it is known as an autapse.