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Vaccinia virus GL-ONC1 was studied in a trial combined with chemo- and radiotherapy as Standard of Care for patients newly diagnosed with head & neck cancer. [107] Herpes simplex virus, adenovirus, reovirus and murine leukemia virus are also undergoing clinical trials as a part of combination therapies. [108]
Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy.
Cancer; Candidiasis ("Thrush") Chagas disease; Chickenpox; Copenhagen disease; Croup; Cystic fibrosis; Cytomegalovirus (the virus most frequently transmitted before birth) Dental caries; Type 1 diabetes; Diphtheria; Duchenne muscular dystrophy; Fifth disease; Congenital Heart Disease; Infectious mononucleosis; Influenza; Intussusception ...
Initial symptoms include fever, rash, aching muscles, sore throat, vomiting and diarrhea, while more advanced symptoms of the disease include delirium, liver failure, shock and organ failure.
Sequencing of the virus from Merkel cell cancers reveals that it generally has tumor-specific mutations that truncate the MCV T antigen. These mutations (which are not found in native virus obtained from nontumor sites) eliminate the T antigen helicase, preventing the integrated virus from replicating independently from the host cancer cell. [10]
An oncovirus or oncogenic virus is a virus that can cause cancer. [4] This term originated from studies of acutely transforming retroviruses in the 1950–60s, [ 5 ] when the term oncornaviruses was used to denote their RNA virus origin. [ 6 ]
Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus.It is also called Human herpesvirus 8, or HHV-8 in short. [2] This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, [3] as well as primary effusion lymphoma, [4] HHV-8-associated multicentric Castleman's disease and KSHV inflammatory cytokine syndrome. [5]
Advisories about enterovirus D68, or EV-D68, have been issued after the CDC noted more children were being hospitalized for severe respiratory illness. A new virus to worry about: EV-D68 can cause ...