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A 2015 meta-analysis supported the "efficacy of saffron as compared to placebo in improving the following conditions: depressive symptoms (compared to anti-depressants and placebo), premenstrual symptoms, and sexual dysfunction. In addition, saffron use was also effective in reducing excessive snacking behavior."
Each dose lasts approximately 30 minutes. [12] Pain relief begins after 6–8 breaths and continues for several minutes after stopping inhalation. [13] The maximum recommended dose is 6 milliliters per day or 15 milliliters per week because of the risk of kidney problems, and it is not recommended to be used on consecutive days. [4]
It is still recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. [16] [17] Symptoms of delirium in hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine. [18]
Saffron's usual substitutes in food—turmeric and safflower, among others—yield a garishly bright yellow that could hardly be confused with that of saffron. Saffron's main colourant is the carotenoid crocin; it has been discovered in the less tediously harvested—and hence less costly—gardenia fruit. Research in China is ongoing. [17]
The usual dosage of etifoxine (as the hydrochloride salt) is 150 to 200 mg per day in divided doses of 50 to 100 mg two to three times per day (e.g., 50 mg–50 mg–100 mg). [ 2 ] [ 7 ] [ 6 ] [ 18 ] [ 1 ] [ 19 ] [ 20 ] It is taken for a few days to a few weeks, but no longer than 12 weeks.
Miindfulness-based stress reduction may be as effective as escitalopram (Lexapro — an SSRI commonly used to treat depression and anxiety), in relieving anxiety symptoms, a new study has found.