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  2. 3D cell culture - Wikipedia

    en.wikipedia.org/wiki/3D_cell_culture

    The intrinsic advantages of 3D cell culture lie in its ability to represent cellular interactions akin to those in-vivo. When appropriately validated, 3D cell culture models can serve as a pivotal intermediary, bridging the gap between conventional 2D cell culture models and in-vivo animal models.

  3. Cellular model - Wikipedia

    en.wikipedia.org/wiki/Cellular_model

    The eukaryotic cell cycle is very complex and is one of the most studied topics, since its misregulation leads to cancers. It is possibly a good example of a mathematical model as it deals with simple calculus but gives valid results. Two research groups [1] [2] have produced several models of the cell cycle simulating several organisms. They ...

  4. Cell-based models - Wikipedia

    en.wikipedia.org/wiki/Cell-based_models

    Cell-based models are mathematical models that represent biological cells as discrete entities. Within the field of computational biology they are often simply called agent-based models [1] of which they are a specific application and they are used for simulating the biomechanics of multicellular structures such as tissues. to study the influence of these behaviors on how tissues are organised ...

  5. Alternatives to animal testing - Wikipedia

    en.wikipedia.org/wiki/Alternatives_to_animal_testing

    Russell and Burch writing six decades ago could not have anticipated some of the technologies that have emerged today. One of these technologies, 3D cell cultures, also known as organoids or mini-organs, have replaced animal models for some types of research. In recent years, scientists have produced organoids that can be used to model disease ...

  6. Cell culture - Wikipedia

    en.wikipedia.org/wiki/Cell_culture

    A 3D cell culture model showed cell growth similar to that of in vivo than did a monolayer culture, and all three cultures were capable of sustaining cell growth. [75] As 3D culturing has been developed it turns out to have a great potential to design tumors models and investigate malignant transformation and metastasis, 3D cultures can provide ...

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