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RegulonDB is a database of the regulatory network of gene expression in Escherichia coli K-12. [1] [2] RegulonDB also models the organization of the genes in transcription units, operons and regulons. A total of 120 sRNAs with 231 total interactions which all together regulate 192 genes are also included.
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is ...
ChIPBase a database for Transcription factor-binding sites, motifs (~1290 transcription factors) and decoding the transcriptional regulation of LncRNAs, miRNAs and protein-coding genes from ~10,200 curated peak datasets derived from ChIP-seq methods in 10 species
YEASTRACT (Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated repository of more than 48000 regulatory associations between transcription factors (TF) and target genes in Saccharomyces cerevisiae, based on more than 1200 bibliographic references. [1]
Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.
transcriptional regulation – controlling the rate of gene transcription for example by helping or hindering RNA polymerase binding to DNA; upregulation, activation, or promotion – increase the rate of gene transcription; downregulation, repression, or suppression – decrease the rate of gene transcription
Plant Transcription Factor Database and Plant Transcriptional Regulation Data and Analysis Platform; Regulation of Gene Expression (MeSH) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ChIPBase An open database for decoding the transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP ...
Regulation of transcription in mammals. An active enhancer regulatory sequence of DNA is enabled to interact with the promoter DNA regulatory sequence of its target gene by formation of a chromosome loop. This can initiate messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the ...