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This is a major piece of evidence that statins work in another way than the lowering of cholesterol (called pleiotropic effects). [35] Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%.
Side effects of statins include muscle pain, increased risk of diabetes, ... albeit at high doses and in combination with other cholesterol-reducing medications.
While it’s important to treat heart disease risks before a first event, statins can cause side effects for some, including muscle pain, headaches, sleep problems and digestive problems.
Comparable to statins and ezetimibe, fibrates are usually well-tolerated with mild adverse reactions, with the exception of gemfibrozil. Some of the more prevalent side effects are minor gastrointestinal disturbances such as abdominal pain and cholithiasis on account of the increased excretion of biliary cholesterol. [23]
Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that
Statins “help reduce the risk of plaque ruptures and stabilize the blood vessels” in addition to reducing cholesterol, Serwer says. These medications are a “first-line therapy, after diet ...