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Tirzepatide and semaglutide are type 2 diabetes drugs that doctors often prescribe for weight loss. Tirzepatide may be more effective because of how it works, but current research is inconclusive.
The researchers suggested that tirzepatide provides a better cost value than semaglutide. In another 2021 study, tirzepatide was also more effective than semaglutide in reducing blood sugar levels in people with type 2 diabetes after 40 weeks.
In the series of SURPASS clinical studies, tirzepatide was “superior at every dose” from 5 mg to 15 mg, lowering A1c by 0.6 percentage points more than semaglutide 1 mg. When it came to weight loss in SURPASS-2, the difference was even more dramatic: -11.4% for tirzepatide vs. -6.7% for semaglutide.
One U.S. study, utilizing a cost needed to treat analysis, has shown that tirzepatide (Zepbound) may offer a better value for money when compared to semaglutide (Ozempic) for weight reduction over 68 to 72 weeks.
When prescribing glucagon-like peptide 1 (GLP-1) medications, many physicians prefer tirzepatide over the more well-known semaglutide due to its superior efficacy in weight loss and A1c...
Tirzepatide at all doses was noninferior and superior to semaglutide. Reductions in body weight were greater with tirzepatide than with semaglutide (least-squares mean estimated treatment...
While tirzepatide produces greater weight loss than semaglutide in patients with T2D, 11 data from head-to-head trials comparing these therapies in patients with overweight or obesity are not yet available.
Semaglutide users had an average 0.40% improvement in HbA1c, and tirzepatide users had an average 0.67% improvement in HbA1c (Table 1b). Conclusion: Semaglutide and tirzepatide reduced weight and improved HbA1c in adults with T1D, with greater weight loss efficacy for tirzepatide.
At all doses, tirzepatide was superior to semaglutide, with estimated treatment differences of −1.9 kg (95% CI, −2.8 to −1.0) with tirzepatide at a dose of 5 mg, −3.6 kg (95% CI, −4.5 to ...
Efficacy: All three tirzepatide doses were noninferior to and also superior to semaglutide with respect to the mean reduction in glycated hemoglobin level. Patients in