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Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. [50]
ATC code R06 Antihistamines for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]
It is unclear if use during pregnancy or breastfeeding is safe. [8] It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year. [8] [10] In 2022, it was the 46th most commonly prescribed medication in the United States, with more than 13 million prescriptions. [11] [12]
Adoption of ICD-10-CM was slow in the United States. Since 1979, the US had required ICD-9-CM codes [11] for Medicare and Medicaid claims, and most of the rest of the American medical industry followed suit. On 1 January 1999 the ICD-10 (without clinical extensions) was adopted for reporting mortality, but ICD-9-CM was still used for morbidity ...
It acts primarily as a strong antagonist of the H 1 receptor (antihistamine, K i = 1.4 nM [29]) and a moderate mACh receptor antagonist (anticholinergic), [2] and also has weak to moderate affinity for the 5-HT 2A, [30] 5-HT 2C, [30] D 2, [31] [32] and α 1-adrenergic receptors, [33] where it acts as an antagonist at all sites, as well.
And a recently detected asteroid, called 2024 YR4, has a 2.2% chance of hitting our planet in 2032. But astronomers are quick to point out that the chances of either asteroid strike are slim.
The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. Diphenhydramine; E. Embramine; M. 4-Methyldiphenhydramine;