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Unus testis, nullus testis (lit. ' one witness, no witness ') is a Latin legal phrase describing a rule of the law of evidence. According to this rule, the uncorroborated testimony of one witness should be discounted because it is deemed to be too unreliable to establish a fact. The English equivalent of the phrase is "one man, no man". [1]
The appendix testis is a Müllerian duct remnant and consists of fibrous tissue and blood vessels within an envelope of columnar epithelium. The appendix testis is attached to the upper pole of the testis and found in the groove between the testis and the epididymis. The appendix epididymis is attached to the head of the epididymis.
As the scrotum and labia majora form in males and females respectively, the gubernaculum aids in the descent of the gonads (both testes and ovaries). [3] The testes descend to a greater degree than the ovaries and ultimately pass through the inguinal canal into the scrotum. [3] The mechanism of this movement is still debated. [3]
The ectopic testis can be in the perineal region, the opposite side of the scrotum, the suprapubic region, the femoral region, or the superficial inguinal pouch. [1]The ectopic testis is initially normal, but if it is ignored after childhood, it may become small and soft, with spermatogenesis arresting and interstitial cell proliferation occurring.
Large testes (macroorchidism) can be a clue to one of the most common causes of inherited generalised learning disability, fragile X syndrome. Stephen Shalet, a leading endocrinologist who works for the Christie Hospital in Manchester, is reported to have told The Observer: "Every endocrinologist should have an orchidometer. It's his stethoscope."
Macroorchidism is a disorder found in males, specifically in children, where a subject has abnormally large testes. The condition is commonly inherited in connection with fragile X syndrome (FXS), which is also the second most common genetic cause of intellectual disability. [1] The condition is also a rare sign of McCune–Albright syndrome. [2]
The tunica albuginea is a dense, [1] [2] blue-white [3] layer of fibrous tissue surrounding the testis. [1] [4] It is the middle of three envelopes forming the capsule of the testis; it is deep to the visceral layer of tunica vaginalis, and superficial to the tunica vasculosa testis (vascular layer of testis).
Manifestations of mixed gonadal dysgenesis are highly variable with asymmetry in gonadal development of testis and streak gonad, accounted for by the percentage of cells expressing XY genotype. [22] [23] The dysgenic testis can have an amount of functional tissue which can produce a level of testosterone, which causes masculinisation. [22] [23]