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Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. [3] Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon ...
There are three categories of disease presentation in Crohn's disease: stricturing, penetrating, and inflammatory. Stricturing disease causes narrowing of the bowel that may lead to bowel obstruction or changes in the caliber of the feces. Penetrating disease creates abnormal passageways (fistulae) between the bowel and other structures, such ...
The advancements in biological therapy greatly changed how IBD is treated. Patients with Crohn's disease and ulcerative colitis show an increase in proinflammatory cytokines such as IL-1, IL-6, IL-8, IL-23, and TNF. [10] In 1988, a monoclonal antibody called infliximab was discovered at New York University's School of Medicine. Infliximab works ...
Ultimately, the review suggests high intakes of red meat, ultra-processed foods, sugar, and saturated fat may be risk factors for IBD development, as well as increase the risk of irritable bowel ...
The clinical presentation of ulcerative colitis depends on the extent of the disease process. [16] Up to 15% of individuals may have severe disease upon initial onset of symptoms. [ 12 ] A substantial proportion (up to 45%) of people with a history of UC without any ongoing symptoms (clinical remission) have objective evidence of ongoing ...
Inflammatory Bowel Diseases is a monthly peer-reviewed medical journal covering all aspects of inflammatory bowel disease. It was established in 1995 and is published by Oxford University Press. [1] It is the official journal of the Crohn's & Colitis Foundation. The editor-in-chief is Fabio Cominelli (Case Western Reserve University). [2]