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You should not use phentermine if you have glaucoma, overactive thyroid, severe heart problems, uncontrolled high blood pressure, advanced coronary artery disease, extreme agitation, or a history of drug abuse.
Patients with a known history should NOT take phentermine. Cardiovascular disease includes coronary artery disease, stroke, irregular heartbeat (arrhythmia), congestive heart failure, and uncontrolled hypertension.
Phentermine is not suitable for people with a history of cardiovascular or valvular heart disease, glaucoma, hyperthyroidism, a history of drug abuse, who are pregnant or breastfeeding, or with agitation.
You shouldn’t take phentermine within 14 days of starting or stopping an MAOI. Taking these drugs together can cause a hypertensive crisis (a dangerous increase in blood pressure).
Do not use this medicine if you also take an MAO inhibitor (MAOI), such as isocarboxazid (Marplan®), phenelzine (Nardil®,), selegiline (Eldepryl®), or tranylcypromine (Parnate®), or if you have used an MAOI within the past 14 days. Using these medicines together may cause serious unwanted effects.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. This drug should not be used with certain medications because very serious interactions may occur.
You shouldn’t take phentermine with monoamine oxidase inhibitors (MAOIs) or fenfluramine (Fintepla). It’s also best to avoid combining stimulant medications, alcohol, and large amounts of caffeine with phentermine.