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NEM is a Michael acceptor in the Michael reaction, which means that it adds nucleophiles such as thiols. The resulting thioether features a strong C–S bond and the reaction is virtually irreversible. Reaction with thiols occur in the pH range 6.5–7.5, NEM may react with amines or undergo hydrolysis at a more alkaline pH.
A Michael reaction is used as a mechanistic step by many covalent inhibitor drugs. Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the ...
The machinery in the kiosks can quickly reproduce brass keys, key fobs, and car keys both with and without transponders. The kiosks are located in various cities across the United States, generally alongside a box retailer, grocery store, or corner store. [7] [8] Originally kiosks would only allow access to keys via a finger print scan. [9]
The single most important tip is that car consumers should always store their key fob in a metal container or a metal wire bag often called a Faraday cage that prevents the key fob from ...
The Hauser donor is an aromatic sulfone or methylene sulfoxide with a carboxylic ester group in the ortho position. The Hauser acceptor is a Michael acceptor. In the original Hauser publication ethyl 2-carboxybenzyl phenyl sulfoxide reacts with pent-3-ene-2-one with LDA as a base in THF at −78 °C. [12] Hauser annulation
Keegan-Michael Key is making 2025 his year. In an exclusive interview with PEOPLE, the actor and comedian, 53, says he currently has two top-secret "bucket list" projects he's working on. "I don't ...