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In general, medical therapy is non-curative and is used for mild-to-moderate regurgitation or in patients unable to tolerate surgery. [15] In acute MR secondary to a mechanical defect in the heart (i.e., rupture of a papillary muscle or chordae tendineae), the treatment of choice is mitral valve surgery.
In The Framingham Heart Study presence of any severity of tricuspid regurgitation, ranging from trace to above moderate was in 82% of men and in 85.7% of women. [2] Mild tricuspid regurgitation tend to be common and benign and in structurally normal tricuspid valve apparatus can be considered a normal variant. [1]
Valvular heart disease resulting from rheumatic fever is referred to as rheumatic heart disease. Acute rheumatic fever, which frequently manifests with carditis and valvulitis, [20] is a late sequela of Group A beta-hemolytic streptococcus infection in the throat, often lagging the initial infection by weeks to months. [21]
Because pulmonic regurgitation is the result of other factors in the body, any noticeable symptoms are ultimately caused by an underlying medical condition rather than the regurgitation itself. [3] However, more severe regurgitation may contribute to right ventricular enlargement by dilation, and in later stages, right heart failure. [8]
Mitral valve prolapse is frequently associated with mild mitral regurgitation, [15] where blood aberrantly flows from the left ventricle into the left atrium during systole. In the United States , MVP is the most common cause of severe, non-ischemic mitral regurgitation. [ 4 ]
In The Framingham Heart Study, presence of tricuspid regurgitation of mild severity or greater, was present in about 14.8% of men and 18.4% of women. [20] Mild tricuspid regurgitation tends to be common and, in the presence of a structurally normal tricuspid valve apparatus, can be considered a normal variant. [21]
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