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Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [10] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [10]
In areas of low clarithromycin resistance, including the United States, a 14-day course of "triple therapy" with an oral proton pump inhibitor, clarithromycin 500 mg, and amoxicillin 1 g (or, if penicillin allergic, metronidazole 500 mg), all given twice daily for 14 days, is recommended for first-line therapy. This regimen can achieve rates of ...
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
The metronidazole tablet may have an unpleasant metallic taste, deteriorating drug compliance. [47] This medication may also induce rare side effect in the central nervous system, including neurotoxicity ( encephalopathy , peripheral neuropathy , seizure ).
For the first episode of recurrent C. difficile infection, the 2017 IDSA guidelines recommend oral vancomycin at a dose of 125 mg four times daily for 10 days if metronidazole was used for the initial episode. If oral vancomycin was used for the initial episode, then a prolonged oral vancomycin pulse dose of 125 mg four times daily for 10–14 ...
Sulfadiazine is available in multiple generic tablets of 500 mg. For urinary tract infections, the usual dose is 4 to 6 grams daily in 3 to 6 divided doses. [4] Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. [1]
In clinical pharmacology, dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week").
Therefore, potential risks of side effects and effectiveness depend on the type of antibiotic administered. [ 63 ] Antibiotics such as metronidazole , tinidazole , cephamandole , latamoxef , cefoperazone , cefmenoxime , and furazolidone , cause a disulfiram -like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde ...