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Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
However, chronic granulomatous disease leads to inadequate H 2 O 2 production, while myeloperoxidase deficiency is characterized by a lack of myeloperoxidase to interact with present H 2 O 2. [ 1 ] [ 2 ] [ 3 ] [ 7 ] Testing with NADPH oxidase-specific assays can lead to positive results for chronic granulomatous disease and negative results for ...
Definition [ edit ] The greatest common divisor (GCD) of integers a and b , at least one of which is nonzero, is the greatest positive integer d such that d is a divisor of both a and b ; that is, there are integers e and f such that a = de and b = df , and d is the largest such integer.
Neutrophil oxidative burst test (or chronic granulomatous disease (CGD) test) is a measure of neutrophil oxidation and is a useful assay in the diagnosis of chronic granulomatous disease and is also a useful means to determine the overall metabolic integrity of phagocytosing neutrophils. The NADPH oxidase enzyme is missing in CGD. From total ...
Although female carriers can have a mild form of G6PD deficiency (dependent on the degree of inactivation of the unaffected X chromosome – see Skewed X-inactivation), homozygous females have been described; in these females there is co-incidence of a rare immune disorder termed chronic granulomatous disease (CGD). [citation needed]
The other key term in the above definition is the word "organized" which refers to a tight, ball-like formation. The macrophages in these formations are typically so tightly clustered that the borders of individual cells are difficult to appreciate. Loosely dispersed macrophages are not considered to be granulomas.
CGD conducts research within a range of topics that impact global poverty and people of the developing world. Topics include aid effectiveness, education, globalization and global health, as well as the impact of trade and migration on development.
Prolonged grief disorder (PGD), also known as complicated grief (CG), [1] traumatic grief (TG) [2] and persistent complex bereavement disorder (PCBD) in the DSM-5, [3] is a mental disorder consisting of a distinct set of symptoms following the death of a family member or close friend (i.e. bereavement).