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Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis. [1] [2]
Lipoxygenases (EC 1.13.11.-) (LOX) are a family of (non-heme) iron-containing enzymes, more specifically oxidative enzymes, most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4-pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate ...
Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene. [ 5 ] [ 6 ] It catalyzes the conversion of lysine residues into its aldehyde derivative allysine . [ 7 ]
Valheim is an upcoming survival and sandbox video game by the Swedish developer Iron Gate Studio and published by Coffee Stain Studios. [1] It was released in early access on 2 February 2021 for Linux and Windows via Steam , and for Xbox One and Xbox Series X/S on 14 March 2023.
The Cre-Lox system is widely used to manipulate gene expression in model organisms such as mice in order to study human diseases and drug development. [3] For example, using the Cre-Lox system, researchers are able to study oncogenes and tumor suppressor genes and their role in the development and progression of cancer in mouse models.
LOXL2 is an enzyme that is up-regulated in several types of cancer and is associated with a poorer prognosis. [8] [9] LOXL2 changes the structure of histones (proteins that are attached to DNA) [10] and thus changes the shape of the cells, making it easier for the cancer cells to metastasize.
Raptor is a family of methane/liquid oxygen rocket engines under development by SpaceX since the late 2000s, [2] although LH2/LOX propellant mix was originally under study when the Raptor concept development work began in 2009. [15] When first mentioned by SpaceX in 2009, the term "Raptor" was applied exclusively to an upper stage engine ...
Liquid oxygen has a clear cyan color and is strongly paramagnetic: it can be suspended between the poles of a powerful horseshoe magnet. [2] Liquid oxygen has a density of 1.141 kg/L (1.141 g/ml), slightly denser than liquid water, and is cryogenic with a freezing point of 54.36 K (−218.79 °C; −361.82 °F) and a boiling point of 90.19 K (−182.96 °C; −297.33 °F) at 1 bar (14.5 psi).