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Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent , and gadolinium (Gd 3+ ), and is used in form of the meglumine salt (gadoterate meglumine).
Free Gd 3+ has a median lethal dose of 0.34 mmol/kg (IV, mouse) [27] or 100–200 mg/kg, but the LD50 is increased by a factor of 31 times [28] when Gd 3+ is chelated. [29] The spectrum of adverse drug reactions is greater with gadolinium-based contrast agents than with iodinated contrast agents (radiocontrast agents). [30]
This article about magnetic resonance imaging is a stub. You can help Wikipedia by expanding it.
The most severe reaction to gadobutrol is nephrogenic system fibrosis (NSF) among patients with impaired elimination of the drug. The risk is highest among patients with chronic, impaired kidney function and those with acute kidney injury. NSF may result in death or severe impairment of the skin, muscle, and internal organs. [8]
The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations. The tetracarboxylic acid was first reported in 1976. [2] At the time of its discovery DOTA exhibited the largest known formation constant for the complexation of Ca 2+ and Gd 3+ ions. Modified ...
High levels of niacin, an essential B vitamin, may raise the risk of heart disease by triggering inflammation and damaging blood vessels, according to new research. This type of supplement may ...
Gadodiamide is one of the main GBCA associated with nephrogenic systemic fibrosis (NSF), a toxic reaction occurring in some people with kidney problems. [6] No cases have been seen in people with normal kidney function.
Gadoxetic acid is a gadolinium-based MRI contrast agent. [4] Its salt, gadoxetate disodium , is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals .
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