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Cytarabine-5´-triphosphate is a substrate for SAMHD1. [18] Furthermore, SAMHD1 has been shown to limit the efficacy of cytarabine efficacy in patients. [19] When used as an antiviral, cytarabine-5´-triphosphate functions by inhibiting viral DNA synthesis. [20]
Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the synthesis of DNA by acting as an antimetabolic agent against deoxycytidine (a component of DNA). It is the biologically active form of cytarabine. [1]
Cytarabine (Cytosine ... Medical uses. Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication. ... Toggle the table of ...
The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of folic acid (top). An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. [1]
30833 50773 Ensembl ENSG00000125458 ENSMUSG00000020736 UniProt Q8TCD5 Q9JM14 RefSeq (mRNA) NM_001252377 NM_014595 NM_015807 RefSeq (protein) NP_001239306 NP_055410 NP_056622 Location (UCSC) Chr 17: 75.13 – 75.13 Mb Chr 11: 115.38 – 115.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5', 3'-nucleotidase, cytosolic, also known as 5'(3')-deoxyribonucleotidase, cytosolic type (cdN ...
[4] [6] It contains the liposomal bound daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor. [ 4 ] Medical uses
Alkylating antineoplastic agents have limitations. Their functionality has been found to be limited when in the presence of the DNA-repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). Cross-linking of double-stranded DNA by alkylating agents is inhibited by the cellular DNA-repair mechanism, MGMT.
There is a large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human DNA replication, so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs ...