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Following a single oral dose of sertraline, mean peak blood levels of sertraline occur between 4.5 and 8.4 hours. [5] Bioavailability is likely linear and dose-proportional over a dose range of 150 to 200 mg. [ 5 ] Concomitant intake of sertraline with food slightly increases sertraline peak levels and total exposure. [ 5 ]
Based on this percentage, free concentrations of sertraline would be 2.49 ng/mL (8.13 nM) at the very most, which is only about one-third of the K i value that Tatsumi et al. found with sertraline at the DAT. [8] A very high dosage of sertraline of 400 mg/day has been found to produce peak plasma concentrations of about 250 ng/mL (816 nM). [16]
The recommended maximum daily dose of citalopram and escitalopram was reduced due to concerns with QT prolongation. [92] [93] [94] In overdose, fluoxetine has been reported to cause sinus tachycardia, myocardial infarction, junctional rhythms, and trigeminy.
In the meantime, taking your sertraline dose with bland foods or ginger tea may help alleviate any nausea. ... (that does not mean that this is a treatment for high blood pressure, by the way). ...
Which drugs you currently and how high the dose is. ... Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary ...
Sertraline. Sold under the brand name Zoloft, ... especially if you’ve been taking one at a high dose for a while. If you’re prescribed any type of benzodiazepine, do not abruptly stop taking ...
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