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Bioavailability is likely linear and dose-proportional over a dose range of 150 to 200 mg. [5] Concomitant intake of sertraline with food slightly increases sertraline peak levels and total exposure. [5] There is an approximate 2-fold accumulation of sertraline with continuous administration and steady-state levels are reached within one week. [5]
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]
Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI), but, uniquely among most antidepressants, it shows relatively high affinity for the DAT as well. [ 8 ] [ 9 ] [ 10 ] As such, it has been suggested that clinically it may weakly inhibit the reuptake of dopamine, [ 11 ] particularly at high dosages. [ 12 ]
Sertraline and several other widely used antidepressants can increase your risk of experiencing frequent thoughts about death. The increased risk of these thoughts appears to be present only in ...
Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary between SSRIs. As such, your healthcare provider may suggest ...
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.