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Feline leukemia virus (FeLV) is an RNA virus in the subfamily Oncovirinae belonging to the Retroviridae family. The virus comprises 5' and 3' LTRs and three genes: Gag (structural), Pol (enzymes) and Env (envelope and transmembrane); the total genome is about 9,600 base pairs .
While the causes of cancer in cats are unknown, feline leukemia virus is suspected to be a prime contributor. [2] Other factors suspected to increase rates of feline cancer include toxins from the environment, passive smoking, excessive grooming, or licking parts of the body that have been in contact with an environmental toxin. [2]
Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses. Some of these can be treated and the animal can have a complete recovery. Others, like viral diseases, are more difficult to treat and cannot be treated with antibiotics, which are not effective against viruses.
Short title: Outcomes of Feline Leukemia Virus (FeLV) Infection: Image title: Diagram illustrating the potential outcomes of Feline Leukemia Virus (FeLV) infection in cats, detailing the stages from exposure to the virus through various infection pathways, including abortive, focal/atypical, regressive, and progressive infections, with associated percentages and potential clinical consequences ...
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A vaccine-associated sarcoma (VAS) or feline injection-site sarcoma (FISS) is a type of malignant tumor found in cats (and, often, dogs and ferrets) which has been linked to certain vaccines. VAS has become a concern for veterinarians and cat owners alike and has resulted in changes in recommended vaccine protocols.
Feline viral rhinotracheitis (FHV, aka herpes virus) Feline calicivirus (FCV) Rabies (where the disease is endemic or required by law) Non-core vaccines are recommended only for cats at risk of specific infection. These include: Feline leukemia virus (FeLV) Feline immunodeficiency virus (FIV) Chlamydia felis; Bordetella bronchiseptica
The double stranded DNA is highly stable and easily integrated into a host genome. A few examples of the virus are Moloney murine leukemia virus, xenotropic MuLB-related virus, feline leukemia virus, and feline sarcoma virus. [6] [7] [8] Gammaretroviruses are very popular retroviral vectors in laboratory studies.