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HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR.
HER2 is overexpressed in 20-30% of breast cancers and is commonly associated with poor prognosis. It is therefore an oncogene whose differently spliced variants have been shown to have different functions.
In 1986 Axel Ullrich, a German scientist working at Genentech, first discovered the Her-2 protein and gave a conference about it in which Slamon was present.Afterwards Slamon proposed to work together, since he suspected that a mutation in Her-2 might cause cancer, eventually they found a kind of aggressive breast cancer with a mutation in the gene responsible for the Her-2 protein and started ...
Triple-negative means the cancer does not have estrogen or progesterone receptors and lacks or has very little of the HER2 protein, the organization notes. This cancer has fewer therapies than ...
Cancer is a genetic disease where changes to genes can cause cells to grow and divide out of control. Each cancer can have a unique combination of genetic mutations, and even cells within the same tumour may have different genetic changes. In clinical settings, it has commonly been observed that the same types and doses of treatment can result ...
An MRI found a spot near one of her lymph nodes in her right breast, Munn told People. The ultrasound that followed found two more tumors in her right breast, which turned out to be stage 1 cancer.
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