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In 2005 the landscape of the mammalian genome was described as numerous 'foci' of transcription that are separated by long stretches of intergenic space. [9] While some long ncRNAs are located within the intergenic stretches, the majority are overlapping sense and antisense transcripts that often include protein-coding genes, [23] giving rise to a complex hierarchy of overlapping isoforms. [24]
The roles of non-coding RNAs: Ribonucleoproteins are shown in red, non-coding RNAs in blue. A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein.
SPA lncRNA 5' small nucleolar RNA capped and 3' polyadenylated long noncoding RNA - SRP RNA: signal recognition particle RNA CL00003: ssRNA single stranded RNA - stRNA: small temporal RNA - tasiRNA: trans-acting siRNA - tmRNA: transfer-messenger RNA RF00023: Bacterial RNA molecule with dual tRNA-like and messenger RNA-like properties uRNA U ...
nastypatty (talk · contribs) - Alexander Batchelder - lncRNA ratchelp11 ( talk · contribs ) - Rachel P. - Red tide and types of algal blooms MattyGprotein ( talk · contribs ) - Matt Greenlaw - Rorquals Cladogram
MYC expression is controlled by a wide variety of noncoding RNAs, including miRNA, lncRNA, and circRNA. Some of these RNAs have been shown to be specific for certain types of human tissues and tumors. [29] Changes in the expression of such RNAs can potentially be used to develop targeted tumor therapy.
This lncRNA plays a significant role in mice embryonic development and can be lethal if expressed during prenatal stages. More lncRNAs have been discovered in eukaryotes overtime. One such discovery that allowed for better understanding between H19 functions was a lncRNA called XIST (X inactive-specific transcript).
Cancer LncRNA Census (CLC) Database of long-noncoding RNAs causally implicated in cancer through in vivo, in vitro and other evidence. [15] BIGTranscriptome: High-confidence of coding and noncoding transcriptomes assembled with hundreds of pseudo-stranded and stranded RNA-seq datasets. [16] lncRNAKB
The word transcriptome is a portmanteau of the words transcript and genome.It appeared along with other neologisms formed using the suffixes -ome and -omics to denote all studies conducted on a genome-wide scale in the fields of life sciences and technology.