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Methylcobalamin (mecobalamin, MeCbl, or MeB 12) is a cobalamin, a form of vitamin B 12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group . [ 1 ] Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. [ 2 ]
Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B 9), methylcobalamin (vitamin B 12) and pyridoxal 5'-phosphate (vitamin B 6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). [1]
Vitamin B 12 deficiency; Other names: Hypocobalaminemia, cobalamin deficiency: Image of the cervical spinal cord in vitamin B 12 deficiency showing subacute combined degeneration. . (A) The midsagittal T2 weighted image shows linear hyperintensity in the posterior portion of the cervical tract of the spinal cord (black arrow
Methylcobalamin is also offered as a dietary supplement. [12] There is no advantage to the use of adenosylcobalamin or methylcobalamin forms for the treatment of vitamin B 12 deficiency. [20] [21] [4] Hydroxocobalamin can be injected intramuscularly to treat vitamin B 12 deficiency. It can also be injected intravenously for the purpose of ...
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
In molecular biology, the vitamin B12-binding domain is a protein domain which binds to cobalamin (vitamin B12). It can bind two different forms of the cobalamin cofactor, with cobalt bonded either to a methyl group (methylcobalamin) or to 5'-deoxyadenosine (adenosylcobalamin).
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