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The C57BL/6 mouse was the second-ever mammalian species to have its entire genome published. [1] The dark coat makes the mouse strain convenient for creating transgenic mice: it is crossed with a light-furred 129 mouse, and the desirable crosses can be easily identified by their mixed coat colors. [1]
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
While studying under W. E. Castle, Little began his work with mice, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. In 1921, he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. [2]
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
A dead mouse found in a cage in a clandestine Reedley laboratory is surrounded by decaying carcasses of mice that died previously in this photo taken by city code enforcement officers in April 2023.
All laboratories using vertebrate lab animals in the United States are required by law to have a licensed veterinarian on staff and to adhere to the NIH Guide for the Use and Care of Laboratory Animals, which further stipulates that all protocols, including the sources for obtaining the animals, must be reviewed by an independent committee. [6]
The company also has sites in Hollister and South San Francisco in California. The work done in San Diego—the breeding of rodents that scientists use to test compounds—was moved to Hollister, California. [9] In October 2021, a Japanese subsidiary of Charles River was acquired by Jackson Laboratory for $63M USD. [10]