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The risks of using high-strength minoxidil include an increased likelihood of side effects. When using it as a topical solution, side effects of minoxidil may include: Skin irritation
Side effects from topical and oral minoxidil can differ. When taken orally, minoxidil may cause side effects such as fluid retention, elevated heart rate and increased body hair growth.
Minoxidil (brand name Rogaine®) is a non-prescription topical medication that promotes hair growth and regrowth by restarting the growth phase in dormant hair follicles.
Side effects of oral minoxidil may include swelling of the face and extremities, rapid heartbeat, or lightheadedness. Cardiac lesions, such as focal necrosis of the papillary muscle and subendocardial areas of the left ventricle, have been observed in laboratory animals treated with minoxidil. [ 8 ]
Minoxidil sulfate is formed from minoxidil via sulfotransferase enzymes, with the predominant enzyme responsible, at least in hair follicles, being SULT1A1. [1] [2] Minoxidil sulfate acts as a potassium channel opener, among other actions, and has vasodilating, hypotensive, and trichogenic or hypertrichotic (hair growth-promoting) effects.
Topical glucocorticoids are the topical forms of glucocorticoids. Topical glucocorticoids are used in the treatment of many skin conditions. They provide anti-inflammatory, antimitotic, and immune-system suppressing actions through various mechanisms. [1] Hydrocortisone cream is a type of topical glucocorticoid that is commonly found on the market.