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Phentermine (Adipex-P®, Lomaira®). Phentermine is a stimulant that suppresses appetite by affecting the central nervous system. ... Consider reviews from people who’ve used it successfully (or ...
Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat.
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
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[11] [18] A few other MRAs have also been found to be inactive at VMAT2, such as phentermine and benzylpiperazine (BZP). [11] [18] These findings indicate that VMAT2 activity is non-essential for robust MRA actions. [11] [18] Phenmetrazine does not appear to have been assessed at the trace amine-associated receptor 1 (TAAR1). [19] [20]
The New York Psychiatric Institute, associated with Columbia University, the Research Foundation of the City University of New York, and Mount Sinai Medical Center tested fenfluramine intravenously on more than 100 Black and Hispanic boys between the ages of 6 and 10, with delinquent older brothers, to test the theory that delinquent behavior could be predicted by serotonin levels.
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