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The cyclic structure of proline's side chain locks the angle φ at approximately −65°. [19] Proline acts as a structural disruptor in the middle of regular secondary structure elements such as alpha helices and beta sheets; however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets.
Hyperprolinemia type II results in proline levels in the blood between 10 and 15 times higher than normal, and high levels of a related compound called pyrroline-5-carboxylate. This rare form of the disorder may appear benign at times, [ 2 ] but often involves seizures, convulsions, and intellectual disability.
Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or production of these amino acids is highly dependent on cell type and developmental stage.
Pseudoprolines with substitution in position 2 of the proline ring are named Ser/Thr/Cys-(ψR1,R2 Pro). Due to the preference for a cis-amide bond [ 10 ] with the preceding residue of C2-substituted pseudoprolines, their incorporation results in a kink conformation of the peptide backbone, thus preventing peptide aggregation, self-association ...
1959 Buick LeSabre with characteristic beltline surrounding the exterior Tesla Model 3 with front hood character line flowing into side beltline. The beltline is a line representing the bottom edge of a vehicle's glass panels (e.g. windscreen, side windows and rear window). [1] [2] [3] It also represents the bottom of a vehicle's greenhouse.
Rectilinear III "Highboy" Rectilinear III Lowboy Rectilinear III (and others) grille emblem Rectilinear III "Lowboy" (and others) grille emblem. Rectilinear Research Corporation was a manufacturer of loudspeakers. The company was formed around 1966 and its principal was Morris I. Wiener (alt. sp. "Weiner") of Plandome Manor, New York. [1]
One of the most well known epigenetic mechanisms that proline isomerization plays a role in is the modification of histone tails, specifically those of histone H3. Fpr4 is a PPIase, in the FK507BP group, that exhibits catalytic activity at the proline positions 16, 30, and 38 (also written P16, P30, and P38 respectively) on the N-terminal region of histone H3 in Saccharomyces cerevisiae.
ProLine (company), an electronics brand; Pro-Line Racing, a manufacturer of radio-controlled car accessories; Sport Select, Canadian betting games also known as Pro-Line in some areas; Proline, a line of prosumer camcorders manufactured by Panasonic; ProLine, a software package with a Unix-like shell, used to run bulletin board systems on Apple ...
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