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Date: 12 August 2019: Source: Own work, using following image: . Image source: Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J (2019)."HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. [8] Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer .
Multiplexed error-robust fluorescence in situ hybridization [24] is a highly multiplexed version of smFISH. It uses combinatorial labeling, followed by imaging, and then error-resistant encoding [25] to capture a high number of RNA molecules and spatial localization within the cell. The capture of a large number of RNA molecules enables ...
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HER2_FISH_with_debris.png (609 × 485 pixels, file size: 184 KB, MIME type: image/png) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
Date: 8 May 2012: Source: Jiang H, Bai X, Zhang C, Zhang X (2012). "Evaluation of HER2 gene amplification in breast cancer using nuclei microarray in situ hybridization.Int J Mol Sci 13 (5): 5519-5527.
Flow-FISH was first published in 1998 by Rufer et al. [11] as a modification of another technique for analyzing telomere length, Q-FISH, that employs peptide nucleic acid probes [12] of a 3'-CCCTAACCCTAACCCTAA-5' sequence labeled with a fluorescin fluorophore to stain telomeric repeats on prepared metaphase spreads of cells that have been treated with colcemid, hypotonic shock, and fixation to ...
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