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Florbetapir (18 F), sold under the brand name Amyvid, is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18 that was approved for use in the United States in 2012, [4] as a diagnostic tool for Alzheimer's disease.
Florbetaben, sold under the brand name Neuraceq, is a diagnostic radiotracer developed for routine clinical application to visualize β-amyloid plaques in the brain. It is a fluorine-18 (18 F)-labeled stilbene derivative.
Chemical structure of florbetapir (18 F), with the fluorine-18 atom on top. Dr. Skovronsky established Avid Radiopharmaceuticals in July 2005 with the goal of finding a dye that could be injected into the body, would cross the blood–brain barrier and attach itself to amyloid protein deposits in the brain. [4]
Flortaucipir (18 F) is a radioactive diagnostic agent for adults with cognitive impairment who are being evaluated for Alzheimer's disease. [1]It is indicated for positron emission tomography (PET) imaging of the brain to estimate the density and distribution of aggregated tau neurofibrillary tangles (NFTs), a primary marker of Alzheimer's disease.
[18 F] Florbetapir [18 F] or [11 C] Flumazenil [18 F] Flutemetamol [18 F] Fluorodopa [18 F] Desmethoxyfallypride [18 F] Mefway [18 F] MPPF [18 F] Nifene [11 C] Pittsburgh compound B [11 C] Raclopride [18 F] Setoperone [18 F] or [11 C] N-Methylspiperone [11 C] Verapamil; NIMH maintains a list of CNS radiotracers that may be useful for additional ...
The advantage of 18F-FDG PET for these uses is its much wider availability. Some radioactive tracers used for Alzheimer's are florbetapir 18F, flutemetamol F18, PiB and florbetaben 18F, which are all used to detect amyloid-beta plaques (a potential biomarker for Alzheimer's) in the brain.
In the radiopharmaceutical industry, fluorine-18 is made using either a cyclotron or linear particle accelerator to bombard a target, usually of natural or enriched [18 O]water [2] with high energy protons (typically ~18 MeV).
Florbetaben (18F) Florbetapir (18F) Flortaucipir (18F) Flotufolastat F-18; Fluciclovine (18F) Fluorodeoxyglucose (18F) Fluorodopa; Fluoroestradiol F-18; Flurpiridaz (18F)