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In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), [1] [2] is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes. In other words, it is a group of proteins that associate to remodel the way DNA is packaged.
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans. [1] The RSC complex has ATPase activity in the presence of DNA. [1]
Since the original observation of SMARCB1 mutations in rhabdoid tumors, several more subunits of the human SWI/SNF chromatin remodeling complex have been found mutated in a wide range of neoplasms. [26] The SWI/SNF ATPase BRG1 (or SMARCA4) is the most frequently mutated chromatin remodeling ATPase in cancer. [27]
57492 239985 Ensembl ENSG00000049618 ENSMUSG00000069729 UniProt Q8NFD5 E9Q4N7 RefSeq (mRNA) NM_017519 NM_001363725 NM_001371656 NM_001374820 NM_001374828 NM_001085355 RefSeq (protein) NP_059989 NP_001350654 NP_001358585 NP_001361749 NP_001361757 NP_001078824 Location (UCSC) Chr 6: 156.78 – 157.21 Mb Chr 17: 5.04 – 5.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AT-rich ...
Gene encoding for ARID1A is the most frequently mutated SWI/SNF subunit across cancers. [9] This gene has been commonly found mutated in different cancers leading to loss of function, including gastric cancers, [10] colon cancer, [11] ovarian clear cell carcinoma, [12] liver cancer, [13] lymphoma [14] and pancreatic cancer. [15]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein in humans that is encoded by the SMARCD2 gene. [5] [6] [7]The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin ...
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. [ 5 ] [ 6 ] [ 7 ] Function
57376 Ensembl ENSG00000073584 ENSMUSG00000037935 UniProt Q969G3 O54941 RefSeq (mRNA) NM_003079 NM_020618 RefSeq (protein) NP_003070 NP_003070.3 NP_065643 Location (UCSC) Chr 17: 40.62 – 40.65 Mb Chr 11: 99.1 – 99.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in ...