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Cytochrome P450 oxidases are important enzymes in xenobiotic metabolism.. Xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons.
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
Clinicians use drug detoxification to reduce or relieve withdrawal symptoms while helping an addicted person adjust to living without drug use. Drug detoxification does not aim to treat addiction but rather represents an early step within long-term treatment. Detoxification may be achieved drug-free or may use medications as an aspect of treatment.
Although the body is able to remove xenobiotics by reducing it to a less toxic form through xenobiotic metabolism then excreting it, it is also possible for it to be converted into a more toxic form in some cases. This process is referred to as bioactivation and can result in structural and functional changes to the microbiota. [2]
GSTs are essential in this process because they catalyze the nucleophilic attack of glutathione on various electrophilic residues of xenobiotic substrates, thereby preventing their disruption of vital cellular proteins and nucleic acids. Similar to the mechanism GSTs use for catalyzation of redox reactions, the mechanism for detoxification ...
It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD.
Conversion of epoxides to trans-dihydrodiols presents prototypical EPHX1 reaction. [10] EPHX1 has broad substrate specificity. [19] [20] EPHX1 detoxifies low molecular weight chemicals, e.g., butadiene, benzene, styrene, etc., [21] but more complex compounds as polycyclic aromatic hydrocarbons are rather bioactivated to genotoxic species.
A xenobiotic-sensing receptor is a receptor that binds xenobiotics. [1] They include the following nuclear receptors: [1] Constitutive androstane receptor (CAR) Pregnane X receptor (PXR) CAR and PXR are xenobiotic receptors and they both are members of NR1I nuclear receptor family. The regulate the metabolic pathway for the elimination of ...