Ad
related to: lab values in secondary hyperparathyroidism meaning- About Hypoparathyroidism
HCPs: Hypoparathyroidism goes
beyond hypocalcemia. Learn more.
- Understanding the Disease
Learn about hypoparathyroidism's
prevalence and etiology.
- Diagnosis and Monitoring
Explore guideline recommendations
in managing hypoparathyroidism.
- Addressing PTH Deficiency
See where PTH replacement therapy
may help your patients.
- Patient Burden
Read about the impact on patients'
functioning and well-being.
- Multiorgan Manifestations
See the effects on multiple organs
while using conventional therapy.
- About Hypoparathyroidism
Search results
Results From The WOW.Com Content Network
Secondary hyperparathyroidism is the medical condition of excessive secretion of parathyroid hormone (PTH) by the parathyroid glands in response to hypocalcemia (low blood calcium levels), with resultant hyperplasia of these glands. This disorder is primarily seen in patients with chronic kidney failure.
Hyperparathyroidism is an increase in parathyroid hormone (PTH) levels in the blood. [1] [4] This occurs from a disorder either within the parathyroid glands (primary hyperparathyroidism) or as response to external stimuli (secondary hyperparathyroidism). [1]
Renal osteodystrophy has been classically described as the result of hyperparathyroidism secondary to hyperphosphatemia combined with hypocalcemia, both of which are due to decreased excretion of phosphate by the damaged kidney. [citation needed]
Hyperparathyroidism is a condition caused by overproduction of PTH, and can be divided into three types. [ citation needed ] Primary hyperparathyroidism happens when the normal mechanism of regulation by negative feedback of calcium is interrupted, or in other words the amount of blood calcium would ordinarily signal less production of PTH.
Signs and symptoms include ectopic calcification, secondary hyperparathyroidism, and renal osteodystrophy. Abnormalities in phosphate metabolism such as hyperphosphatemia are included in the definition of the new chronic kidney disease–mineral and bone disorder (CKD–MBD). [3]
Tertiary hyperparathyroidism is defined by autonomous release of parathyroid hormone while in a hypercalcaemic state. Unlike primary hyperparathyroidism, hypercalcemia in the tertiary form is thought to be the result of resolution of secondary hyperparathyroidism rather than adenoma formation alone. [4] [11] [10]
Hyperparathyroidism is confirmed by blood tests such as calcium and PTH levels. A specific test for parathyroid adenoma is sestamibi parathyroid scintigraphy, often referred to as sestamibi scan or, more colloquially, MIBI scan. This nuclear imaging technique reveals the presence and location of pathological parathyroid tissue. [7]
Calcimimetics are used to treat secondary hyperparathyroidism (SHPT). [1] [2] In the treatment of SHPT patients on dialysis calcimimetics does not appear to affect the risk of early death. [3] It does decrease the need for a parathyroidectomy but caused more issues with low blood calcium levels and vomiting. [3]
Ad
related to: lab values in secondary hyperparathyroidism meaning