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Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. [ 1 ] [ 9 ] Typical symptoms range from those of a common cold , such as nasal congestion , rhinitis , and cough , to difficulty breathing as in pneumonia . [ 9 ]
Equine adenovirus 1 can also cause fatal disease in immunocompromised Arabian foals, involving pneumonia and destruction of pancreatic and salivary gland tissue. [31] Tupaia adenovirus (TAV) (tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated from sea lions (Zalophus californianus). [32]
Adenoviral keratoconjunctivitis, also known as epidemic keratoconjunctivitis, is a contagious eye infection, a type of adenovirus disease caused by adenoviruses. [1] It typically presents as a conjunctivitis with a sudden onset of a painful red eye, watery discharge and feeling that something is in the eye. [3]
In August 2022, 9 children in a U.S. case series of hepatitis of unknown cause [7] and 27 of 30 children in a U.K. case series with hepatitis of unknown cause who underwent molecular testing [8] tested positive for human adenovirus type 41 in a sample. It was unclear whether human adenovirus 41 was the cause, however. [citation needed]
Human adenovirus 36 (HAdV-36) or Ad-36 or Adv36 is one of 52 types of adenoviruses known to infect humans. AD-36, first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis, [ 1 ] has long been recognized as a cause of respiratory and eye infections in humans. [ 2 ]
Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral fiber glycoproteins to host receptors, which mediates endocytosis.
Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. [1] Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. It gained regulatory approval in 2005 from China ...
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