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ER-positive is one of the Receptor statuses identified in the classification of breast cancer.Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches look at these together, along with the tumor grade, to categorize breast cancer into several conceptual molecular classes [1] that have different prognoses [2] and may have ...
Breast cancer cells may or may not have many different types of receptors, the three most important in the present classification being: estrogen receptor (ER), progesterone receptor (PR), and HER2/neu. Cells with or without these receptors are called ER positive (ER+), ER negative (ER-), PR positive (PR+), PR negative (PR-), HER2 positive ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 January 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...
The N-terminal of the ER holds the activation function 1 (AF1) domain; the AF2 domain of the ER is contained within the ligand binding domain. The AF2 domain contains binding sites for coactivators. [10] Estrogen is a steroid hormone and can cross the cell membrane freely. It can then bind to an ER, which is located in the cytoplasm of the cell
Classic LCIS and invasive lobular lesions are low-grade ER and PR-positive cancers, referring to the positive expression of Estrogen and Progesterone receptors on the neoplastic cells (determined via immunohistochemistry). [8] These entities are also both classically negative for HER2 (human epidermal growth factor receptor 2).
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