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15–50% (with sudden stopping) [3] [4] Antidepressant discontinuation syndrome , also called antidepressant withdrawal syndrome , is a condition that can occur following the interruption, reduction, or discontinuation of antidepressant medication following its continuous use of at least a month. [ 5 ]
Intimacy Problems. Sertraline and other SSRIs can cause a variety of intimacy side effects, from difficulty climaxing to decreased drive. According to a review of studies published in the journal ...
Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer medications aren’t effective. Atypical antidepressants.
Like other SSRIs, sertraline is associated with sexual side effects, including sexual arousal disorder, erectile dysfunction and difficulty achieving orgasm. While nefazodone and bupropion do not have negative effects on sexual functioning, 67% of men on sertraline experienced ejaculation difficulties versus 18% before the treatment. [92]
Many SSRIs can cause intimate side effects, so the chance of experiencing adverse effects of sertraline (Zoloft) may be similar to experiencing Prozac’s intimate side effects.
Further, they have fewer and milder side effects. Tricyclic antidepressants also have a higher risk of serious cardiovascular side effects, which SSRIs lack. SSRIs act on signal pathways such as cyclic adenosine monophosphate (cAMP) on the postsynaptic neuronal cell, which leads to the release of brain-derived neurotrophic factor (BDNF). BDNF ...